Clinical cell‐based versus cell‐free regenerative endodontics: clarification of concept and term

There is no consensus on the true meaning of clinical regenerative endodontics, and there confusion over concept term. Commonly used terms include revitalization revascularization. The methods for endodontic procedures tissue engineering differ depending whether exogenous delivery cells – called cell therapy, or not. Here, in this review, difference clarified by emphasizing correct terminology: cell-free versus cell-based therapy (CF-RET CB-RET). practised clinically do not fit into modern concepts pulp regeneration but can be categorized as CF-RET. a CB-RET, which so far at trial stage. However, histological examination teeth following treatments reveals healing with repair derived from stem that originate periodontal, bone other tissues. aim endodontics pulp–dentine complex. This review discusses why CF-RET unlikely to regenerate complex current protocols. American Association Endodontists European Society Endodontology have yet recommended autologous transplantation (CB-RERT) aspires regeneration. Therefore, an understanding concept, term, difficulties differences protocols important clinician. rather than being discouraged ideal has been achieved date, acceptable outcome it also accepted medicine. Repair should considered context resolution signs/symptoms necrosis/apical periodontitis generally reliably obtained endodontics.